LunaX™ TissueMatrix – Photocrosslinkable Extracellular Matrix

LunaX™ TissueMatrix is a tunable ECM tailored for 3D spheroid and co-culture models of mesodermal origin, including stromal and endothelial cell types.

Suitable for applications in oncology, vasculogenesis, and drug screening, LunaX™ TissueMatrix offers high reproducibility and intuitive handling—ideal for both expert users and researchers transitioning from 2D to 3D systems.

Matrix Stiffness

Clear

Product Overview

LunaX™ TissueMatrix is a tunable ECM tailored for 3D spheroid and co-culture models of mesodermal origin, including stromal and endothelial cell types.

LunaX™ TissueMatrix supports a wide range of mesodermal applications, including stromal and endothelial co-culture systems, vascular biology studies such as endothelial tube formation, and tumor–stroma interaction models.

Its stiffness can be finely modulated via visible light-mediated crosslinking, enabling the modelling of diverse physiological and pathological microenvironments. This makes LunaX™ TissueMatrix ideal for investigating processes such as tumor-stroma interactions, cellular invasion, and therapeutic responses.

Kit Contents

Each kit conatins everything you need for precise, tunable 3D cell culture:

Low Stiffness Kit (0 – 6.5 kPa):

✔ 5 mL LunaGel™ ECM (2x solution)

✔ 5 vials of freeze-dried cytocompatible photoinitiator

High Stiffness Kit (0 – 25 kPa):

✔ 5 mL LunaGel™ ECM (1.5x solution)

✔ 5 vials of freeze-dried cytocompatible photoinitiator

How LunaX™ TissueMatrix Works

The LunaX™ TissueMatrix are tunable hydrogel systems engineered to enable precise modulation of ECM stiffness while preserving cellular viability and function.

Crosslinking is driven by a photoinitiator that undergoes activation upon exposure to cytocompatible blue visible light (λ = 405 nm), initiating a controlled polymerisation reaction. Stiffness can be incrementally increased by extending the duration of light exposure, allowing fine-tuned adjustment of the mechanical microenvironment. This approach facilitates the generation of physiologically relevant 3D models that recapitulate tissue-specific or disease-associated ECM mechanics, including progressive stiffening observed in tumorigenesis and fibrosis.

Features

Tunable Stiffness

Easy and Fast

Biocompatible

Bioactive Motifs

Consistent Quality

Protease Degradeable

Workflow

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Outdated 2D Cell Culture is Holding Research Back

For decades, researchers have relied on flat, artificial systems that distort biological behavior and lack clinical relevance. These outdated models fail to reflect the complexity of real human tissue, leading to limited accuracy, unpredictable results, and delayed breakthroughs.

LunaX™ TissueMatrix – Photocrosslinkable Extracellular Matrix