A Whitepaper preview of the LunaGel™ Ultrapure GelMA, Photocrosslinkable Extracellular Matrix (ECM)

LunaX™ PureMatrix – Photocrosslinkable Extracellular Matrix

LunaX™ PureMatrix is a highly purified, tunable ECM with minimal endotoxin content (<10 EU/g). LunaX™ PureMatrix is the preferred choice for immuno-oncology models, and translational research where immune activation must be tightly controlled.

Matrix Stiffness

Clear

Product Overview

LunaX™ PureMatrix is a highly purified, tunable ECM with minimal endotoxin content (<10 EU/g). It is the preferred choice for immuno-oncology models and translational research where immune activation must be tightly controlled.

Endotoxins, particularly lipopolysaccharides, can elicit unintended immune activation, compromising the validity of therapeutic assays and immune-cell interactions in 3D culture. This is especially critical in macrophage assays, immuno-oncology models, and translational studies requiring precise immune modulation.

LunaX™ PureMatrix addresses this challenge with ultra-low endotoxin levels (<10 EU/g), providing an immune-compatible matrix for sensitive applications. Its tunable mechanical properties allow precise control of stiffness to replicate both healthy and pathological tissue environments, improving physiological relevance and experimental reproducibility.

Kit Contents

Each kit conatins everything you need for precise, tunable 3D cell culture:

Low Stiffness Kit (0 – 6.5 kPa):

✔ 5 mL LunaGel™ ECM (2x solution)

✔ 5 vials of freeze-dried cytocompatible photoinitiator

High Stiffness Kit (0 – 25 kPa):

✔ 5 mL LunaGel™ ECM (1.5x solution)

✔ 5 vials of freeze-dried cytocompatible photoinitiator

How LunaX™ PureMatrix Works

The LunaX™ PureMatrix are tunable hydrogel systems engineered to enable precise modulation of ECM stiffness while preserving cellular viability and function.

Crosslinking is driven by a photoinitiator that undergoes activation upon exposure to cytocompatible blue visible light (λ = 405 nm), initiating a controlled polymerisation reaction. Stiffness can be incrementally increased by extending the duration of light exposure, allowing fine-tuned adjustment of the mechanical microenvironment. This approach facilitates the generation of physiologically relevant 3D models that recapitulate tissue-specific or disease-associated ECM mechanics, including progressive stiffening observed in tumorigenesis and fibrosis.

Features

Tunable Stiffness

Easy and Fast

Biocompatible

Bioactive Motifs

Consistent Quality

Protease Degradeable

Workflow

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Outdated 2D Cell Culture is Holding Research Back

For decades, researchers have relied on flat, artificial systems that distort biological behavior and lack clinical relevance. These outdated models fail to reflect the complexity of real human tissue, leading to limited accuracy, unpredictable results, and delayed breakthroughs.

LunaX™ PureMatrix – Photocrosslinkable Extracellular Matrix