Accelerate Your Preclinical R&D with Human-Relevant 3D Models.​

Partner with Gelomics to leverage our expert-led services. We de-risk your drug candidates using our validated 3D tissue platforms and predictive AI-powered analysis.

Bioassays & Disease Models

Explore our 3D disease models and quantitative readouts for early discovery and translational assessment across efficacy, immuno-oncology, safety, and mechanism of action. Choose from establishde models or request a custom design.

ONCOLOGY & TME

Evaluate compounds in physiologically relevant 3D tumor contexts

Models

  • Tumor Spheroids (Breast, Lung, Colon, GBM, and more)
  • Tumor-Stroma Co-cultures (with CAFs)
  • Patient-Derived Organoids (PDOs)
  • Metastasis & Invasion Models
Key Assays
  • 3D Growth Inhibition (IC50) & Kinetics
  • Tumor Invasion & Migration (“Starburst” assays)
  • Drug Penetration & Distribution

IMMUNO-ONCOLOGY (IO)

Quantify immune infiltration, activation, and killing in tumor co-cultures

Available

  • Immune-Tumor Co-cultures (PBMCs, T-Cells, NK Cells)
  • Checkpoint Inhibitor Evaluation Models
  • Bi-specific Antibody / T-Cell Engager Models

Key Assays

  • Immune Cell Infiltration Analysis
  • Immune-Mediated Tumor Killing (Live-cell imaging)
  • T-Cell Activation Markers (Flow Cytometry)
  • ADCC Assays

TOXICOLOGY & SAFETY

Identify organ-specific liabilities early with 3D tissue models

Available
  • Liver Spheroids (HepG2, Primary, iPSC)
  • Cardiac Organoids (iPSC-derived)
  • Nephrotoxicity (Kidney) Models

Key Assays

  • Cytotoxicity (ATP, LDH Release, Cell Viability)
  • Mitochondrial Toxicity (Membrane Potential)
  • Oxidative Stress (ROS Detection)
  • CYP P450 Induction/Inhibition

MECHANISTIC & SPECIALIZED

Interrogate MoA in angiogenesis, fibrosis, and BBB models with multi-omics readouts

Available
  • Angiogenesis (Sprouting & Tube Formation)
  • Fibrosis Models (Stellate Cell Activation)
  • Blood-Brain Barrier (BBB) Models
Key Assays
  • High-Content Imaging & Analysis
  • Secretome Analysis (Cytokines/Chemokines)
  • Gene Expression (qPCR, RNA-Seq)

Our Contract Research Capabilities

We offer end-to-end services, from bespoke assay design to high-throughput screening and predictive data analysis.

Custom 3D Assay Development

We design and build bespoke 3D cell culture models (spheroids, organoids, co-cultures) tailored to your specific drug target, cell type, or disease state.

Assay Validation & Optimization

Our team provides rigorous validation of 3D models against known standards and reference compounds to ensure robust, reproducible, and reliable data for your go/no-go decisions.

High-Throughput Screening
Utilize our automation-ready NovaX™ platform to rapidly screen your compound libraries for efficacy and toxicity in highly reproducible 3D human-relevant models.
Mechanistic & TOX Studies
Leverage our tuneable LunaX™ platform for deep mechanistic studies, ADME/Tox profiling, and advanced safety assessments to better predict human response
Immuno-Oncology Assays
We specialize in complex 3D co-culture models, including T-cell engager assays, immune cell infiltration, and checkpoint inhibitor screens in a human-relevant tumor microenvironment.
AI-Powered Data Analysis

Go beyond raw data. Our AI platform provides predictive modeling, IC50 calculations, toxicology profiling, and ‘in-silico’ optimization based on your study results.

Infrastructure & Equipment

Access world-class instrumentation. We utilize state-of-the-art technology to ensure the highest resolution, sensitivity, and throughput for your studies.

Advanced imaging & microscopy

Confocal Laser Scanning Microscopy

  • Zeiss LSM 980 with Airyscan 2 (High-sensitivity, super-resolution)
  • Nikon A1R Confocal System
  • Leica White-Light Laser Confocal Microscope

Electron & Ion Microscopy

  • FIB-SEM: FEI Quanta 3D Dual Beam Focused Ion Beam Microscope
  • HIM: Zeiss Helios Helium Ion Microscope (Surface imaging & nanofabrication)

Nanoscale Characterization

  • BMT Multiscan & NT-MDT Solver Pro Atomic Force Microscopes (AFM)

Flow Cytometry & Cell Analysis

Cell Sorting & Analysis

  • BD FACSAria Fusion (High-speed sorting, anaerobic capability)

  • Cytek Aurora CS (Full spectrum profiling)

  • BD LSR Fortessa X-20 (High-parameter immunophenotyping)

 

Metabolic & Analyte Profiling

  • Seahorse XFe96 (Cellular metabolism analysis)

  • Luminex Magpix (Multiplex analyte detection)

  • Simoa HD-X Analyser (Ultra-sensitive biomarker detection)

Preteometric & Mass Spectrometry

LC-MS/MS Platforms

  • Thermo Scientific Orbitrap Exploris 480 & LTQ Orbitrap Elite

  • SCIEX TripleTOF 6600+ & 5600+ Systems

  • SCIEX Triple Quadrupole Trap 6500

 

Targeted Quantitation

  • Agilent 6495 Triple Quadrupole LC/MS

  • Shimadzu Triple Quadrupole 8050 & 8040 LC-MS/MS

Genomics & Molecular Biology

Gene Expression Analysis

  • QuantStudio 7 Flex & 6 Flex Real-Time PCR Systems

  • BioRad QX200 Droplet Digital PCR (ddPCR) System

 

Sequencing

  • Illumina NovaSeq 6000 (High-throughput NGS)

  • Ion Proton & Ion S5 Systems

  • PromethION (Oxford Nanopore Long-read sequencing)

Physical & Mechanical Characterization

Mechanical Testing

  • MTS 810 Integrated Testing System (Fatigue & Fracture)
  • Zwick Roell Kappa DS (Electromechanical Creep Testing)
  • Instron 6800 Series Universal Testing Systems

 

Surface & Material Analysis

  • Kratos Axis Supra X-Ray Photoelectron Spectroscopy (XPS)
  • Nano-indentation for tissue stiffness mapping
  • Rheology systems for hydrogel characterization
 

Histology & Pathology

Tissue Processing & Histology

  • Thermo Scientific Excelsior ES Tissue Processor

  • Shandon Histocentre Embedding Station

  • Leica RM2265 Fully Automated Rotary Microtome

  • Leica CM Series Cryostats (Fresh-frozen sections)

 

Digital Pathology & Staining

  • Leica Autostainer XL with CV5030 Coverslipper

  • 3D Histech Pannoramic Slide Scanner (Brightfield & Fluorescence)

  • Quantitative image analysis software

Advanced imaging & microscopy

Confocal Laser Scanning Microscopy

  • Zeiss LSM 980 with Airyscan 2 (High-sensitivity, super-resolution)
  • Nikon A1R Confocal System
  • Leica White-Light Laser Confocal Microscope

Electron & Ion Microscopy

  • FIB-SEM: FEI Quanta 3D Dual Beam Focused Ion Beam Microscope
  • HIM: Zeiss Helios Helium Ion Microscope (Surface imaging & nanofabrication)
  • SEM: Scanning Electron Microscopy with Back Scatter Detection
  • TEM: In-situ Transmission Electron Microscopy

Nanoscale Characterization

  • BMT Multiscan & NT-MDT Solver Pro Atomic Force Microscopes (AFM)

Flow Cytometry & Cell Analysis

Cell Sorting & Analysis

  • BD FACSAria Fusion (High-speed sorting, anaerobic capability)

  • Cytek Aurora CS (Full spectrum profiling)

  • BD LSR Fortessa X-20 (High-parameter immunophenotyping)

 

Metabolic & Analyte Profiling

  • Seahorse XFe96 (Cellular metabolism analysis)

  • Luminex Magpix (Multiplex analyte detection)

  • Simoa HD-X Analyser (Ultra-sensitive biomarker detection)

Preteometric & Mass Spectrometry

LC-MS/MS Platforms

  • Thermo Scientific Orbitrap Exploris 480 & LTQ Orbitrap Elite

  • SCIEX TripleTOF 6600+ & 5600+ Systems

  • SCIEX Triple Quadrupole Trap 6500

 

Targeted Quantitation

  • Agilent 6495 Triple Quadrupole LC/MS

  • Shimadzu Triple Quadrupole 8050 & 8040 LC-MS/MS

Genomics & Molecular Biology

Gene Expression Analysis

  • QuantStudio 7 Flex & 6 Flex Real-Time PCR Systems

  • BioRad QX200 Droplet Digital PCR (ddPCR) System

 

Sequencing

  • Illumina NovaSeq 6000 (High-throughput NGS)

  • Ion Proton & Ion S5 Systems

  • PromethION (Oxford Nanopore Long-read sequencing)

Physical & Mechanical Characterization

Mechanical Testing

  • MTS 810 Integrated Testing System (Fatigue & Fracture)
  • Zwick Roell Kappa DS (Electromechanical Creep Testing)
  • Instron 6800 Series Universal Testing Systems

 

Surface & Material Analysis

  • Kratos Axis Supra X-Ray Photoelectron Spectroscopy (XPS)
  • Nano-indentation for tissue stiffness mapping
  • Rheology systems for hydrogel characterization
 

Histology & Pathology

Tissue Processing & Histology

  • Thermo Scientific Excelsior ES Tissue Processor

  • Shandon Histocentre Embedding Station

  • Leica RM2265 Fully Automated Rotary Microtome

  • Leica CM Series Cryostats (Fresh-frozen sections)

 

Digital Pathology & Staining

  • Leica Autostainer XL with CV5030 Coverslipper

  • 3D Histech Pannoramic Slide Scanner (Brightfield & Fluorescence)

  • Quantitative image analysis software

Don't see what you are looking for?

This section highlights our core infrastructure, but we have access to a significantly wider range of equipment and specialized facilities. Please contact us to inquire about specific needs not listed above.

A Collaborative Project Journey

We work as an extension of your team, providing transparent communication and expert guidance at every step.

Phase 1: Consultation & Scoping

We begin with a deep-dive consultation to understand your project goals, drug candidates, target pathways, and key questions. Together, we define the project scope, deliverables, and timelines.

Phase 2: Assay Development & Validation

If a custom model is required, our scientists develop the 3D assay and perform rigorous validation studies. We establish QC metrics and run feasibility studies to ensure the model is robust and fit-for-purpose.

Phase 3: Screening & Execution

With a validated assay, we execute the screening campaign. This can range from high-throughput screens on thousands of compounds to complex, long-term mechanistic studies on a few lead candidates.

Phase 4: Data Analysis & Reporting

Our data science team processes the results using our LunaXCloud™ AI engine. We provide a comprehensive report including raw data, high-content images, statistical analysis, and predictive insights.

Phase 5: Project Review & Next Steps

We conclude with a final review meeting to discuss the results, answer questions, and provide expert recommendations for follow-up studies or next steps in your development pipeline.

Why Partner with Gelomics?

We are more than a CRO. We are your partner in predictive, human-relevant preclinical research.

Human-Relevant Data

Generate predictive data that translates. Our models mimic human physiology, reducing reliance on poor animal proxies.

Speed & Efficiency

Our high-throughput platforms and streamlined workflows deliver data and insights in weeks, not months.

Integrated Platform

We are a single partner for your needs: from proprietary biomaterials and 3D platforms to AI-powered data analysis.

Quality & Reproducibility

As an ISO 9001:2015 certified company, we deliver high-quality, reproducible data you can trust for critical decisions.

Let’s DISCUSS Your Next Project

Reach out to our scientific team to discuss your research needs and learn how our 3D models can de-risk your pipeline.

Phone: 1800 865 060

Email: info@gelomics.com

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