From groundbreaking research to life-saving therapies, explore how Gelomics is transforming drug development with LunaGel’s 3D cell culture technology.
3D cell culture is an advanced technique in cell biology that allows cells to grow in an environment that closely mimics their natural state in the body. Unlike traditional 2D cell culture, where cells are grown in flat, rigid surfaces like plastic dishes, 3D cell culture enables cells to grow in three-dimensional structures, providing a more physiologically relevant model of how cells behave in vivo.
Compared to traditional 2D cultures, which grow cells in flat monolayers with limited spatial context, 3D cultures more closely mimic the physiological conditions of human tissues. They recreate essential factors such as hypoxia, natural stiffness, and acidic microenvironments, enabling more accurate modeling of complex biological interactions, including immune responses and tumor microenvironments. This enhanced physiological relevance bridges the gap between in vitro studies and human biology, improving the predictive value of preclinical research.
| Condition | 3D Cell Culture | 2D Cell Culture | Human |
|---|---|---|---|
|
Oxygen (hypoxia) |
< 5% |
21% |
0-3% |
|
Stiffness |
200-4,000 Pa |
~3×109 Pa |
200-4,000 Pa |
|
pH |
Acidic (<7) |
Buffered (pH 7.2) |
Acidic (<7) |
|
Glucose |
Limiting |
Not limiting |
Limiting |
|
Immune cells |
Admix |
None |
Full |
|
Growth factors |
Human |
– |
Human |
|
Tumor growth |
Weeks/months |
Days/weeks |
Months/years |
|
Tumor Microenvironment |
Moderate (human) |
Limited |
Complex |
|
Heterogeneity |
Model specific |
Limited |
Complex |
3D cell culture has revolutionized biological research by bridging the gap between traditional cell culture and actual biological systems. By replicating tissue-like structures, it enables:
Reducing false positives and negatives in drug screening.
Enabling better study of diseases such as cancer, fibrosis, and neurodegenerative disorders.
Supporting the development of artificial organs and tissue engineering.
3D cell culture is not just a method; it’s a paradigm shift in how we study and understand biological systems. By providing a more accurate representation of in vivo environments, it has the potential to accelerate scientific discoveries and improve healthcare outcomes.
Expedite the discovery of drug candidates by leveraging high-throughput biofabrication to create more physiologically relevant and biomimetic models.
3D bioprinting enables the creation of patient-specific models using cell-friendly biofabrication techniques, driving a transformative shift in healthcare.
Our 3D cell culture advances disease modeling by replicating complex tissue environments for more accurate research.
Bioprinting revolutionizes disease modeling by creating realistic tissue structures for more accurate insights and therapies.
Passed in December 2022, the FDA Modernization Act 2.0 allows the use of cutting-edge alternatives to animal testing for drug development, such as cell-based assays and computer models. This pivotal shift accelerates the development of safer, more human-relevant drugs while reducing costs and ethical concerns tied to animal testing.
At Gelomics, our advanced 3D cell culture solutions—including hydrogels and scaffolds—empower researchers to create realistic human tissue models. By adopting these technologies, you can align with the FDA’s updated guidelines, reduce development expenses, and fast-track drug discovery with greater precision and efficiency.
Boost your studies with the advanced capabilities of 3D tissue culture.
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60 Musk Avenue
Kelvin Grove, QLD 4059
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