From groundbreaking research to life-saving therapies, explore how Gelomics is transforming drug development with LunaGel’s 3D cell culture technology.
Revolutionizing Cell Research with 3D Cell Culture
3D cell culture is an advanced technique in cell biology that allows cells to grow in an environment that closely mimics their natural state in the body. Unlike traditional 2D cell culture, where cells are grown in flat, rigid surfaces like plastic dishes, 3D cell culture enables cells to grow in three-dimensional structures, providing a more physiologically relevant model of how cells behave in vivo.
Clinical Relevance of In Vitro Model Systems
Compared to traditional 2D cultures, which grow cells in flat monolayers with limited spatial context, 3D cultures more closely mimic the physiological conditions of human tissues. They recreate essential factors such as hypoxia, natural stiffness, and acidic microenvironments, enabling more accurate modeling of complex biological interactions, including immune responses and tumor microenvironments. This enhanced physiological relevance bridges the gap between in vitro studies and human biology, improving the predictive value of preclinical research.
| Condition | 3D | 2D | In Vitro |
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Oxygen (hypoxia) |
< 5% |
21% |
0-3% |
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Stiffness |
200-4,000 Pa |
~3×109 Pa |
200-4,000 Pa |
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pH |
Acidic (<7) |
Glucose |
Limiting |
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Immune cells |
Admix |
None |
Full |
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Growth factors |
Human |
– |
Human |
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Tumor growth |
Weeks/months |
Days/weeks |
Months/years |
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Tumor Microenvironment |
Moderate (human) |
Limited |
Complex |
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Heterogeneity |
Model specific |
Limited |
Complex |
3D cell culture has revolutionized biological research by bridging the gap between traditional cell culture and actual biological systems. By replicating tissue-like structures, it enables:
Reducing false positives and negatives in drug screening.
Enabling better study of diseases such as cancer, fibrosis, and neurodegenerative disorders.
Supporting the development of artificial organs and tissue engineering.
Expedite the discovery of drug candidates by leveraging high-throughput bio-fabrication to create more physiologically relevant and biomimetic models.
3D tissue culture enables the creation of patient-specific models using cell-friendly biofabrication techniques, driving a transformative shift in healthcare.
Our 3D cell culture advances disease modeling by replicating complex tissue environments for more accurate research.
Bioprinting revolutionizes disease modeling by creating realistic tissue structures for more accurate insights and therapies.
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LunaX™ |
Basement Membrane Extracts |
Synthetic Hydrogels |
Poly-saccharide Hydrogels |
Peptide Hydrogels |
Collagen Hydrogels |
Fibrin Hydrogels |
Thermo-plastic Scaffolds |
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Physiological ECM stiffness |
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Mechanically tuneable ECM |
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Biomimetic ECM |
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Cell attachment |
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Proteolytic degradation |
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Batch-to-batch consistency |
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Working at room temperature |
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No unwanted growth factor |
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Reproducibility |
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The Alternative Methods To Animal Testing For Drug Development
Passed in December 2022, the FDA Modernization Act 2.0 allows the use of cutting-edge alternatives to animal testing for drug development, such as cell-based assays and computer models. This pivotal shift accelerates the development of safer, more human-relevant drugs while reducing costs and ethical concerns tied to animal testing.
At Gelomics, our advanced 3D cell culture solutions—including hydrogels and scaffolds—empower researchers to create realistic human tissue models. By adopting these technologies, you can align with the FDA’s updated guidelines, reduce development expenses, and fast-track drug discovery with greater precision and efficiency.
Whether you’re looking to build a complex 3D disease model, run a preclinical drug screen, or tap into expert analytical services — Gelomics is here to help.
Boost your studies with the advanced capabiliities of 3D tissue culture.
